Main Project
In cooperation with our collaborators in the Divisions of Neonatology and Neuropediatrics at the UKE, we aim at translating findings from basic research into improved clinical management of neonatal and childhood epilepsies. To this end, we will use our mouse lines in which the activity of Kv7/KCNQ channels (mediating the M current) or HCN channels (mediating I(h)) is under control of the Tet-Off system to investigate the changes at molecular, cellular, and systemic levels.
One major goal of this research program is to understand the mechanisms of epileptogenesis and neuronal synchronization in hyperexcitable neuronal networks caused by dysfunctional ion channels to be able to develop new strategies for the prevention and cure of neonatal and childhood epilepsies. To combine research and clinical work, our ENP team is affiliated with both the Center for Molecular Neurobiology (ZMNH) and the Center for Obstetrics and Pediatrics.
In cooperation with our collaborators in the Divisions of Neonatology and Neuropediatrics at the UKE, we aim at translating findings from basic research into improved clinical management of neonatal and childhood epilepsies. To this end, we will use our mouse lines in which the activity of Kv7/KCNQ channels (mediating the M current) or HCN channels (mediating I(h)) is under control of the Tet-Off system to investigate the changes at molecular, cellular, and systemic levels.
One major goal of this research program is to understand the mechanisms of epileptogenesis and neuronal synchronization in hyperexcitable neuronal networks caused by dysfunctional ion channels to be able to develop new strategies for the prevention and cure of neonatal and childhood epilepsies. To combine research and clinical work, our ENP team is affiliated with both the Center for Molecular Neurobiology (ZMNH) and the Center for Obstetrics and Pediatrics.